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Psychedelics The 5-HT2 receptor family plays a crucial role in regulating the activity of amygdalar microcircuits and projections, modulating both excitatory and inhibitory neurons, in parallel to what is seen in the cerebral cortex. An electron microscopy immunocytochemical study showed localization of 5-HT2A receptors in both the parabrachial and paranigral regions of the VTA, with label identified primarily as dendrites and unmyelinated axons . Dendrites commonly showed 5-HT2A receptor immunoreactivity colocalized with tyrosine hydroxylase. Thus, 5-HT2A receptor activation may directly affect local dendritic release of dopamine as well as release of dopamine in mesocortical and mesolimbic terminal fields. By contrast, when these investigators used a bath solution with an ionic composition that closely mimicked brain interstitial fluid, spontaneous rhythmic oscillations appeared that could be continuously maintained and were nearly identical to those observed in vivo. Slow oscil